diff --git a/packages/react-templates/src/components/Select/SimpleSelect.tsx b/packages/react-templates/src/components/Select/SimpleSelect.tsx
index f3e8b40fe14..4aedaae43af 100644
--- a/packages/react-templates/src/components/Select/SimpleSelect.tsx
+++ b/packages/react-templates/src/components/Select/SimpleSelect.tsx
@@ -80,6 +80,10 @@ const SimpleSelectBase: FunctionComponent<SimpleSelectProps> = ({
   };
 
   const _onSelect = (_event: ReactMouseEvent<Element, MouseEvent> | undefined, value: string | number | undefined) => {
+    if (isDisabled) {
+      return;
+    }
+
     onSelect && onSelect(_event, value);
     setSelected(initialOptions.find((o) => o.value === value));
     onToggle && onToggle(true);
diff --git a/packages/react-templates/src/components/Select/__tests__/SimpleSelect.test.tsx b/packages/react-templates/src/components/Select/__tests__/SimpleSelect.test.tsx
index 71a59f70dc1..6c68e35970a 100644
--- a/packages/react-templates/src/components/Select/__tests__/SimpleSelect.test.tsx
+++ b/packages/react-templates/src/components/Select/__tests__/SimpleSelect.test.tsx
@@ -238,3 +238,26 @@ test('Matches snapshot', async () => {
 
   expect(asFragment()).toMatchSnapshot();
 });
+
+test('ignores selection after the open simple select becomes disabled', async () => {
+  const user = userEvent.setup();
+  const onSelect = jest.fn();
+  const props = {
+    initialOptions: [
+      { content: 'Apple', value: 'apple', selected: true },
+      { content: 'Orange', value: 'orange' }
+    ],
+    onSelect
+  };
+
+  const { rerender } = render(<SimpleSelect {...props} />);
+  const toggle = screen.getByRole('button', { name: 'Apple' });
+  await user.click(toggle);
+
+  rerender(<SimpleSelect {...props} isDisabled />);
+  expect(toggle).toBeDisabled();
+  await user.click(screen.getByText('Orange'));
+
+  expect(onSelect).not.toHaveBeenCalled();
+  expect(toggle).toHaveTextContent('Apple');
+});